SENSITIVITY OF PATHOGENIC AND OPPORTUNISTIC MICROORGANISMS TO PROBIOTIC STRAINS IN THE LIGHT OF PERSONALIZED PROBIOTIC THERAPY

T. Suranova
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Abstract

The purpose of the study. To study the sensitivity of clinical strains of pathogenic and opportunistic bacteria and fungi to microorganisms that are part of probiotic preparations. Materials and methods. The sensitivity of 93 cultures of pathogenic and opportunistic microorganisms (UPM) isolated from the feces of patients with intestinal dysbiosis to strains of probiotic bacteria isolated from commercial probiotic preparations was studied: L. plantarum 8RA-3, E. coli M-17, B. subtilis strain VKPM B-10641, E. faecium SF-68, S. boulardii CNCM I-745 by delayed antagonism method. Results. It was found that pathogenic microorganisms showed low and moderate sensitivity to the probiotic strain of L. plantarum. Sensitivity to the probiotic strain of B. subtilis was detected in S. aureus strains, low or completely absent in P. aeruginosa, Klebsiella spp., S. marcescens. The most sensitive to the probiotic strain were clinical strains of E. coli. Conclusion. UPM and pathogenic microorganisms isolated from the gastrointestinal tract of patients with dysbiosis have different sensitivity to probiotic strains: from high to several probiotics to its complete absence. The empirical approach in prescribing a probiotic does not guarantee a therapeutic effect, which makes it expedient to personify the selection of a probiotic based on an assessment of its antimicrobial activity against isolated pathogens.
基于个性化益生菌治疗的致病性和机会性微生物对益生菌菌株的敏感性
研究的目的。目的:研究致病菌、机会性细菌和真菌临床菌株对益生菌制剂中微生物的敏感性。材料和方法。采用延迟拮抗法,研究了从肠道失调患者粪便中分离的93株病原菌和条件微生物(UPM)对商业益生菌制剂中分离的植物乳杆菌8RA-3、大肠杆菌M-17、枯草芽孢杆菌VKPM B-10641、大肠杆菌f -68、博氏杆菌CNCM I-745的敏感性。结果。结果表明,病原菌对植物乳杆菌的敏感性为低、中度。金黄色葡萄球菌对枯草芽孢杆菌的敏感性较高,铜绿假单胞菌、克雷伯菌、粘质葡萄球菌对枯草芽孢杆菌的敏感性较低或完全不存在。对该菌最敏感的是临床菌株大肠杆菌。结论。从生态失调患者胃肠道中分离的UPM和致病微生物对益生菌菌株的敏感性不同:从高到几种益生菌到完全没有益生菌。处方益生菌的经验方法并不能保证治疗效果,这使得根据对分离病原体的抗菌活性评估来拟人化益生菌的选择是权宜之计。
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