Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Faiz Rasul, R. Saif, H. M. Jehangir, Zainab Rizvi, S. Wahid, Khurram Nadeem
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Abstract

Background: Biological behaviour of Odontogenic Keratocyst (OKC) is aggressiveness than others Odontogenic Cysts (OCs) like Dentigerous Cyst (DCs) and Periapical Cyst/Residual Cysts (RCs). The aim of the study was to determine clinicopathological features and expression of Ki-67 in Odontogenic Cysts of the oral cavity. Methodology: This cross-sectional study was conducted at de’Montmorency College of Dentistry (DCD from Feb, 2020 to Feb, 2022 after approval from Institutional Review Board (IRB) of DCD. A total 78 cases of OCs were collected from hospitals which are affiliated with the DCD. Routine lab process for Hematoxylin & Eosin and Immunohistochemistry was performed. Data entry and statistical analysis was carried out in SPSS 21. A Chi- square test was applied to observe the association between cyst and Ki-67. P value < 0.05 was taken as statistically significant.     Results: Among total 78 cases the mean age was 25.08 ±14.5 years with an age range of 6-70 years. Most OCs (64.1%) were reported in males than females (35.89%). Most OCs were reported in mandible (56.4%. Ki-67 expression in OKC was high 7.7%, low in 76.9% and negative in 15.4%). Most of the DCs and RCs expressed low expression of Ki-67 (84.6% and 76.9% respectively).   Conclusion: Most of the odontogenic cysts expressed low expression of Ki-67 while few cases of OKC and DC expressed high expression. Keywords: Dentigerous Cyst, Odontogenic Keratocyst, Immunohistochemistry, Ki-67, Odontogenic Cysts, Periapical Cyst, Radicular Cyst.
Ki-67在牙源性角化囊肿、牙源性囊肿和根状囊肿中的临床病理特征及表达
背景:牙源性角化囊肿(OKC)的生物学行为比其他牙源性囊肿(OCs)如牙源性囊肿(DCs)和根尖周囊肿/残留囊肿(RCs)更具侵袭性。本研究的目的是确定口腔牙源性囊肿的临床病理特征和Ki-67的表达。方法:经DCD机构审查委员会(IRB)批准,本横断面研究于2020年2月至2022年2月在de 'Montmorency College of Dentistry (DCD)进行。共有78例OCs病例从DCD附属医院收集。进行苏木精、伊红和免疫组织化学常规实验室检查。使用SPSS 21进行数据录入和统计分析。采用卡方检验观察囊肿与Ki-67之间的关系。P值< 0.05为差异有统计学意义。结果:78例患者平均年龄25.08±14.5岁,年龄范围6 ~ 70岁。男性居多(64.1%),女性居多(35.89%)。大多数OCs发生在下颌骨(56.4%)。Ki-67在OKC中高表达(7.7%),低表达(76.9%),阴性(15.4%)。大多数dc和rc低表达Ki-67(分别为84.6%和76.9%)。结论:Ki-67在牙源性囊肿中表达低,在OKC和DC中表达高。关键词:牙源性囊肿,牙源性角化囊肿,免疫组织化学,Ki-67,牙源性囊肿,根尖周囊肿,根状囊肿
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