Preparation of Transdermal Films of Nifedipine: Ex-vivo and In-vitro Studies

Pharmaceutical Methods Pub Date : 2017-08-15 DOI:10.5530/PHM.2017.8.22

K. Venkateswarlu, C. N. Babu, S. Triveni, B. Kiran

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Abstract

Objective: The aim of present study was to prepare and evaluate the transdermal films (TFs) of Nifedipine (NFDP). Methods: The TFs were prepared by solvent evaporation technique and twelve formulations of NFDPTFs were prepared by taking HPMC E15 and Eudragit L100 in different ratios. Polyethylene glycol (15%) and Dimethyl sulfoxide (DMSO) were incorporated as plasticizer and permeation enhancer respectively. DMSO was incorporated in the formulations F7-F12 but it was absent in F1-F6. Results: The prepared TFs were evaluated for weight variation, thickness, folding endurance, drug content, moisture absorption, moisture content determination, mechanical properties and ex-vivo permeation. Mechanical properties revealed that the formulations F4 and F10 were found to be strong enough but not brittle. Hence, the formulations F4 and F10 were selected for ex-vivo studies. The formulations F4 and F10 showed maximum drug permeation within 24 h and formulation with permeation enhancer showed highest drug permeation than formulation without permeation enhancer. Conclusion: It could be concluded that the formulation with permeation enhancer (F10) showed highest permeability through the rat skin than formulation without permeation enhancer.

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硝苯地平透皮膜的制备:离体和体外研究

目的:制备硝苯地平(NFDP)透皮膜并对其进行评价。方法:采用溶剂蒸发法制备TFs，将HPMC E15与乌龙茶L100按不同比例配制成12个NFDPTFs配方。聚乙二醇(15%)和二甲基亚砜(DMSO)分别作为增塑剂和渗透增强剂加入。配方F7-F12中加入了DMSO，而配方F1-F6中不含DMSO。结果:对制备的tf进行了重量变化、厚度、折叠耐力、药物含量、吸湿率、含水率测定、力学性能和体外渗透性能的评价。力学性能表明，配方F4和F10具有足够的强度，但不脆。因此，我们选择配方F4和F10进行离体研究。F4和F10在24 h内的药物透性最大，添加透性增强剂的药物透性高于未添加透性增强剂的。结论:加透性促进剂(F10)的大鼠皮肤透性高于不加透性促进剂的大鼠皮肤透性。

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Pharmaceutical Methods

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