Examination Subclinical Inflammatory Markers and Plasma Neutrophil Gelatinase-Associated Lipocalin in Obsessive-Compulsive Disorder

Abstract

Background: Inflammation has a role in the etiopathogenesis of obsessive-compulsive disorder (OCD). Aims: We investigated the relationship of disease and disease severity with plasma neutrophil gelatinase-associated lipocalin (NGAL) subclinical evaluated platelet (PLT) PLT–lymphocyte ratio (PLR), PLT- distribution witdth (PDW), neutrophil– lymphocyte ratio (NLR), C-reactive protein (CRP), and NGAL levels analyzed in relation to an inflammatory Results: A significant difference was found between disease severity and the PLT count, PDW, and NGAL values. PDW and NGAL values have relationship with disease severity by linear regression analysis. A significant difference was found the OCD with higher CRP, PDW, and a lower PLT value and showed a relationship between the PDW value by ROC analysis. Conclusion: This study was novel in reporting a significant relationship between the PDW level and the disease, and between the PDW and NGAL levels and disease severity in patients diagnosed with OCD.