ASSOCIATION OF GENOTYPES OF POLYMORPHISM NOS3 WITH MACROANGIOPATHIES IN PATIENTS WITH HYPERTONIC DISEASE COMBINED WITH TYPE 2 DIABETES MELLITUS

Abstract

The purpose - to study the probability of association of genotypes of polymorphism NOS3 with macroangiopathies in patients with artherial hypertension (AH) with type 2 diabetes mellitus (DM). Material and methods . 100 patients with AH and type 2 DM and were examined. In all persons the lesions of the arteries of mixed type were verified. The alleles of the polymorphic sites of the synthetase gene of nitric oxide 3 (NOS3, Gene ID: 4846, locus-7q36, polymorphism -786T> C transversion, dbSNP-rs2070744) were studied. Results. The distribution of genotypes NOS3 polymorphism in AG and DM2 group characterized by a probable deviation from the Hardy-Weinberg equilibrium (p<0.01). In monolocal analysis of NOS3 alleles and genotypes with risk of macroangiopathy, a significant difference was found (p <0.05). The allele -786C associated with an increased risk (2.55) of mixed-type vascular lesions vs. control group (OR = 4,27; 95% CI=1,86 - 9.77; p<0.05). It was set decreased (4,46 times) frequency of protective allele -786T in AG and DM 2 (p<0.05), and homozygous "risk" allele C (2 times) vs. control group (95% CI=0.10-0,50; p<0.05). Conclusions. It was set the probable differences and decreased the frequency of "protective" alleles and genotypes in patients with hypertension and diabetes mellitus with macroangiopathy.