Study of the diffusion process in films sodium salt of carboxymethyl cellulose – drug

Abstract

The transport properties of medicinal films based on sodium salt of carboxymethylcellulose and the antibiotic amikacin sulfate have been studied in this work. It has been shown that the process of sorption of water vapor by such films and the release of a drug from them proceeds in an abnormal diffusion mode, which is explained by the slowdown of relaxation processes in glassy polymers, which include the sodium salt of carboxymethylcellulose. An increase of the amount of the introduced drug is accompanied by a regular decrease in the diffusion coefficients of both the process of sorption of water vapor and the release of amikacin from the films. It is noted that the formed films of sodium salt of carboxymethylcellulose-amikacin sulfate dissolve in water during the day and do not provide a prolonged release of the drug. To reduce the solubility of the films in water, the surface modification of the polymer film with calcium chloride has been carried out. It has been found that the modification does not lead to a change in the diffusion mode, but is accompanied by a regular change in the diffusion coefficients – the longer the formed films were kept in a calcium chloride solution, the lower the diffusion coefficients of the sorption of water vapor by medicinal films and the diffusion coefficients of the release of the drug amikacin from the film. It is argued that the surface modification of polymer films based on the sodium salt of carboxymethylcellulose is an effective way of imparting to them the effect of prolonging the release of a drug.