Functionalized multi-walled carbon nanotube/silver nanoparticle (f-MWCNT/AgNP) nanocomposites as non-enzymatic electrochemical biosensors for dopamine detection

IF 4.2 3区材料科学 Q2 MATERIALS SCIENCE, COMPOSITES

Nanocomposites Pub Date : 2021-01-02 DOI:10.1080/20550324.2021.1948242

I. Anshori, Lavita Nuraviana Rizalputri, Raih Rona Althof, Steven Sean Surjadi, S. Harimurti, G. Gumilar, B. Yuliarto, M. Handayani

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引用次数: 28

Abstract

Abstract Dopamine (DA) is an important neurotransmitter in the kidney, cardiovascular system, and central nervous system, which abnormality is associated with many diseases. In this work, we synthesized a functionalized multi-walled carbon nanotube/silver nanoparticle (f-MWCNT/AgNP) nanocomposites as the biosensing material to detect DA. The SEM, EDS, and TEM characterizations indicated the success of the functionalization process with MWCNT as the base material. The values of the linear range, the limit of detection (LOD), and the selectivity of the nanocomposite were all obtained from the Differential Pulse Voltammetry (DPV) measurements. The obtained LOD value was 0.2778 µM in the linear range of 0–8 µM, which is lower than the required concentration value for detecting DA in human urine (0.3–3 µM). The biosensor’s high selectivity on DA with the presence of other human-related biofluids was also reported. These results show that f-MWCNT/AgNP nanocomposites are a promising biosensor material for the detection of DA. Graphical Abstract

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功能化多壁碳纳米管/纳米银(f-MWCNT/AgNP)纳米复合材料作为多巴胺检测的非酶电化学生物传感器

多巴胺(DA)是肾脏、心血管系统和中枢神经系统中重要的神经递质，其异常与许多疾病有关。在这项工作中，我们合成了一种功能化的多壁碳纳米管/银纳米颗粒(f-MWCNT/AgNP)纳米复合材料作为检测DA的生物传感材料。SEM, EDS和TEM表征表明MWCNT作为基材的功能化过程是成功的。通过差分脉冲伏安法(DPV)测量得到了纳米复合材料的线性范围、检出限(LOD)和选择性。在0 ~ 8µM的线性范围内，LOD值为0.2778µM，低于检测人体尿液中DA所需的浓度(0.3 ~ 3µM)。该生物传感器在存在其他人类相关生物体液的情况下对DA具有高选择性。这些结果表明，f-MWCNT/AgNP纳米复合材料是一种很有前途的检测DA的生物传感器材料。图形抽象

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