Half-times of irradiation recovery in accelerated partialbreast irradiation: Incomplete recovery as a potentially dangerous enhancer of radiation damage

Fowler Jf
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引用次数: 3

Abstract

Purpose: To compare clinical results from accelerated partial breast irradiation with predictions from different half-times of recovery of radiation damage. Method: Three published results of excessive late complications led to an editorial [1] which was a “wake up call” to the possible hazards of fractions spaced close together such as two fractions of 3.85 Gy a day on five consecutive days. These results are re-examined here using linear quadratic modelling with mono-exponential and bi-exponential recovery kinetics. Results: Although clinical results showed rather high proportions of severe complications, only in one of the three studies discussed in reference [1] complications were severe enough to cause it to be terminated. Since then other studies with the same doses have reported acceptable results. However, none of these complication rates are predicted to be tolerable, if mono-exponential kinetics with a single T 1⁄2 of ~4 hours is assumed. Conclusions: Better matches to clinical results can be found by assuming bi-exponential recovery with 50%50% components of 0.3 hand 4 h, and  = 3 Gy, for late complications. There is continuing need for data from more clinical results, especially concerning various tumour types.
加速乳房部分照射中照射恢复的一半:不完全恢复是辐射损伤的潜在危险增强因素
目的:比较加速乳房部分照射的临床效果与不同半期放射损伤恢复的预测结果。方法:三篇已发表的过量晚期并发症的研究结果引发了一篇社论[1],这篇社论对间隔较近的分数(例如连续5天每天两次3.85 Gy)可能造成的危害“敲响了警钟”。这些结果在这里使用线性二次模型与单指数和双指数恢复动力学重新检查。结果:虽然临床结果显示严重并发症的比例相当高,但文献[1]所讨论的3项研究中只有1项并发症严重到需要终止。从那时起,其他使用相同剂量的研究报告了可接受的结果。然而,如果假设单指数动力学为1 / 2 ~4小时,这些并发症的发生率预测都是不可容忍的。结论:对于晚期并发症,假设双指数恢复为50%50%,0.3手4 h,= 3 Gy,与临床结果吻合较好。仍然需要更多临床结果的数据,特别是关于各种肿瘤类型的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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