Determination of Cyproheptadine Hydrochloride Drugs in Pure Form and In Their Pharmaceutical Preparation with Pyridinium Fluorochromate (PFC) Reagent

Abstract

In this paper simple and convenient visual titrimetric method have been described for the determination of Cyproheptadine hydrochloride (CPH) i.e. an antihistamine drug in pure form and in its dosage forms with pyridinium fluoro chromate (PFC) reagent. The principle of this method involves the oxidation of Cyclohepten ring of the Cyproheptadine hydrochloride (CPH) by a known excess of potassium iodate in sulphuric acid medium followed by iodometric titration in presence of reagent pyridinium fluoro chromate (PFC). The reagent pyridinium fluoro chromate (PFC) used in this method is a versatile oxidizing agent of chromium (VI). The value of percentage error, coefficient of variation (CV) and standard deviation (SD) have been calculated for accuracy and precision of result.