Ethanolic leaf extract of Chrysophyllum albidum on sperm analysis, hormonal profile, SOD and testicular histology of adult male wistar rats.

Onyeka C Anna, F. Oladapo
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引用次数: 6

Abstract

The purpose of the present study was to evaluate the effects of ethanolic leaf extract of Chrysophyllum albidum on hormones and sperm analysis of laboratory rats. Fifteen male rats weighing 230-250g were completely randomised into three groups: A-C. Animals in Group A (control) were orally administered with 0.5ml of distilled water once daily for 21 days while those in Groups B and C, received 500 and 1000mg/kg body weight of the extract respectively), and effect of the treatment on the testes was investigated. Significant increase (p<0.05) were recorded in the body weights and also the weight of the testis. The treatment caused increase in motility, morphology, and number of spermatozoa in cauda epididymidis. Histologically, testes in rats treated with the plant extract showed no alterations in the seminiferous tubules when compared to the control. However hormonal assay showed significantly reduced levels (p<0.05) of FSH, LH and Testosterone in experimental groups while there was increase in the activity of SOD, which was dose dependent. The results thus suggest that C. albidum treatment does not cause suppression of spermatogenesis but decrease the hormonal profile.
金菊叶乙醇提取物对成年雄性wistar大鼠精子分析、激素谱、SOD及睾丸组织学的影响。
本研究旨在探讨金菊叶乙醇提取物对实验大鼠激素和精子分析的影响。15只体重230 ~ 250g的雄性大鼠完全随机分为三组:A-C组。A组(对照组)灌胃蒸馏水0.5ml,每天1次,连续灌胃21 d; B组和C组灌胃蒸馏水500和1000mg/kg体重),观察对睾丸的影响。体重和睾丸重量显著增加(p<0.05)。处理后附睾尾精子的活力、形态和数量增加。组织学上,与对照组相比,接受植物提取物治疗的大鼠睾丸的精管没有变化。激素测定结果显示,各实验组大鼠FSH、LH和睾酮水平均显著降低(p<0.05), SOD活性升高(且呈剂量依赖性)。结果表明,紫花莲治疗不会抑制精子发生,但会降低激素水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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