Diagnostic Approach to Developing Asymmetry in Opportunist Screening Mammography; Correlation of Ultrasound, Magnetic Resonance Imaging, and Histopathologic Findings with Developing Asymmetry: A Cross-sectional Study

IF 0.4 Q4 ONCOLOGY
N. Sadighi, Morteza Ghassed, Z. Hosseini, A. Alikhassi
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引用次数: 1

Abstract

Background: Developing asymmetries are uncommon mammographic findings with a chance of being associated with malignancy. Objectives: The current study aimed at correlating ultrasound, magnetic resonance imaging (MRI) findings, and histopathology of patients with developing focal asymmetry in opportunist screening mammograms setting, and presents a diagnostic approach to developing asymmetry. Methods: This was a cross-sectional study on a database of opportunist screening mammography at the Breast Clinic, Cancer Center, at Tehran University of Medical Sciences from January 2017 to December 2018. Mammogram screenings (n = 12,169) were evaluated for developing asymmetry. Findings of mammography, ultrasound, MRI findings, and histopathology of patients with developing asymmetry were collected and analyzed. Results: Fifty-four cases (0.44%) had developed asymmetry in screening mammograms. After excluding 18 patients with considering exclusion criteria, the data of 36 patients were analyzed. The summation artifact was the etiology of developing asymmetry in 11 (30.5%) patients. Ultrasound was performed in 28 patients, and 14 (38.8%) patients had no correlated findings. All 3 malignant cases had ultrasound correlates, and a significant association existed between sonography and the risk of malignancy in patients having developing asymmetry (P = 0.003). Three malignant cases of the study underwent MRI, 1 with segmental clumped non-mass enhancement, and 2 showed a mass with rim enhancement. A significant association was revealed between a family history of breast cancer (P = 0.04) and developing asymmetry. The positive predictive value of developing asymmetry for malignancy was 8.3%. Conclusions: Patients having developing asymmetry should be evaluated for malignancy, using supplementary techniques, such as additional mammographic views, ultrasound primarily, or MRI. A biopsy is required for indeterminate findings.
机会性乳房x线筛查中发展不对称的诊断方法超声、磁共振成像和组织病理学结果与发展中的不对称的相关性:一项横断面研究
背景:发展中的不对称是不常见的乳房x线检查结果,有可能与恶性肿瘤有关。目的:本研究的目的是在机会主义筛查乳房x光检查中,将发生局灶性不对称的患者的超声、磁共振成像(MRI)结果和组织病理学相关联,并提出一种诊断方法。方法:这是一项针对德黑兰医科大学癌症中心乳腺诊所2017年1月至2018年12月的机会主义乳房x光筛查数据库的横断面研究。乳房x光检查(n = 12,169)评估是否出现不对称。收集和分析发展中不对称患者的乳房x光检查、超声检查、MRI检查和组织病理学检查结果。结果:54例(0.44%)出现乳房x线筛查不对称。在考虑排除标准排除18例患者后,对36例患者的资料进行分析。11例(30.5%)患者发生不对称的病因是累加伪影。28例患者行超声检查,14例(38.8%)患者无相关发现。3例恶性病例超声检查均有相关性,发生不对称的患者超声检查与恶性肿瘤发生风险有显著相关性(P = 0.003)。本研究的3例恶性病例行MRI检查,1例为节段性块状非肿块强化,2例为肿块边缘强化。乳腺癌家族史与不对称发育之间存在显著关联(P = 0.04)。恶性肿瘤发展不对称的阳性预测值为8.3%。结论:有发展不对称的患者应该评估恶性肿瘤,使用补充技术,如额外的乳房x光片,主要是超声,或MRI。如发现不明确,需行活检。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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