Simultaneous determination of dopamine and uric acid using a glassy carbon paste electrode modified with copper- para red complex

Abstract

A simple approach based on cyclic voltammetry (CV) was developed for the simultaneous determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA) using a modified glassy carbon paste electrode (GCPE). In the present study, analytical parameters were optimized and electrochemical performance of modified electrode was investigated. The calibration curves were obtained over the range of 15.97-157.98 μmol L-1 dopamine and 15.97-195.35 μmol L-1 uric acid. Detection limits of 12.38 μmol L-1 dopamine and 3 μmol L-1 uric acid were also obtained at pH 7.0. The modified electrode was used for practical application for the detection of dopamine and uric acid in the real samples of uric acid and dopamine injection, human serum and urine samples.