A study of the prescribing pattern of antihypertensive drugs in a Tertiary Care Teaching Hospital of Andaman & Nicobar Island

International Journal of Pharmacological Research Pub Date : 2017-05-28 DOI:10.7439/IJPR.V7I5.4143

DineshC.M. Naidu, A. Vardhan

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引用次数: 1

Abstract

Introduction: Hypertension is the increased systolic blood pressure of ?140 mm Hg or diastolic blood pressure of ?90 mm Hg. The antihypertensive drugs currently available are chosen on the basis of their efficacy, side-effects, and cost. Accordingly, a need to survey the pattern of usage of antihypertensive drugs is must, to see if the current usage is rational and in concordance with current guidelines for treatment of hypertension. Therefore this study was carried out with the aim of analyzing the pattern of antihypertensive drugs being prescribed and its adherence with JNC-8 guidelines, in a tertiary care Teaching hospital of Andaman & Nicobar Islands, India.Material & methods: A cross-sectional, observational study was done in ANIIMS, Port Blair, India over a period of 6 months from October 2016 to March 2017, in which analysis of the prescriptions of patients of essential Hypertension was done. A total of 870 prescriptions were analyzed based on age group, gender, number of antihypertensives, combination/ or monotherapy. The results obtained were expressed as percentages & proportion and were compared with JNC-8 Guidelines.Observations: In this study, a total of, 870 prescriptions were analyzed and it was observed that male patients with hypertension were 586(67.3%), and female patients were 284(32.7%), with male: female ratio of 2.05:1. Also most common therapy was the combination therapy in 630(72.4%) patients, out of which a CCB+ Diuretic combination was the commonest in 318(50.4%), followed by ACE-I + Beta Blocker combination in 180(28.6%) patients. Most common Drug used as monotherapy was Diuretics in 110(45.8%) patients, followed by Calcium channel blockers in 82(34.2%) patients, followed by ARBs in 48(20.0%) patients.Conclusion: The trend of hypertension is on the rise, if treated rationally this disease can be overcome. This study suggests the trend of prescribing of antihypertensive drugs in ANIIMS Port Blair, India and will provide a baseline data for similar studies in future.

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安达曼&尼科巴岛三级保健教学医院降压药处方模式研究

高血压是指收缩压升高140 mm Hg或舒张压升高90 mm Hg。目前的降压药物是根据其疗效、副作用和成本来选择的。因此，有必要调查降压药的使用模式，看看目前的使用是否合理，是否符合目前的高血压治疗指南。因此，本研究在印度安达曼和尼科巴群岛的一家三级保健教学医院开展，目的是分析抗高血压药物的处方模式及其对JNC-8指南的遵守情况。材料与方法:2016年10月至2017年3月，在印度布莱尔港ANIIMS进行了一项为期6个月的横断面观察性研究，对原发性高血压患者的处方进行了分析。根据年龄、性别、降压药数量、联合或单一治疗对870张处方进行分析。所得结果以百分比和比例表示，并与JNC-8指南进行比较。观察:本研究共分析处方870张，其中男性高血压患者586例(67.3%)，女性284例(32.7%)，男女比例为2.05:1。630例(72.4%)患者中最常见的是联合治疗，其中最常见的是CCB+利尿剂联合治疗(318例)(50.4%)，其次是ACE-I +受体阻滞剂联合治疗(180例)(28.6%)。最常用的单药是利尿剂(110例，45.8%)，其次是钙通道阻滞剂(82例，34.2%)，其次是arb(48例，20.0%)。结论:高血压有上升趋势，合理治疗是可以克服的。本研究提示了印度布莱尔港ANIIMS抗高血压药物的处方趋势，并将为今后类似研究提供基线数据。

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International Journal of Pharmacological Research

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