A Model of Anatomically Opposed Ischaemia: Revisited

Abstract

This study aims to gain further understanding of anatomically opposed ischaemia, or "ischaemic ST-segment counterpoise", by simulating body surface potential distributions resulting from two regions of partial thikcness ischaemia in the left ventricle during the ST-segment.The finite volume method was used to solve the passive bidomain equation in a torso with an idealised model of the heart. Regions of ischaemia of varying size were placed in various positions in the anterior and posterior regions of the ventricular wall.Simulations show that the sources associated with the anterior ischaemic region dominated the body surface potential distribution, irrespective of the relative sizes of the two ischaemic regions. However, further modelling is required to establish a theoretical basis to understand ischaemic ST-segment counterpoise.