Development of the spectrophotometric method for the quantitative determination of phenolic compounds calculated with reference to 6-gingerol in tablets based on a dry ginger extractACT

W. A. Malek, V. Grudko, O. Ruban, N. Herbina, О. V. Gvozdik
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Abstract

the spectrophotometric method for the quantitative determination of the total of phenolic calculated with to 6-gingerol in tablets a dry ginger extract. study average of g containing 0.3 g of a dry extract (manufacturer – Dnipro) obtained by the direct compression method. The spectrophotometric method was used to determine phenolic compounds calculated with reference to 6-gingerol. Results and discussion . The spectral characteristics of a standard sample of 6-gingerol, a predominant substance among biologically active phenolic compounds of ginger, have been studied. It has been shown that its absorption spectrum in the range from 220 to 400 nm contains one absorption band with a maximum at 281 nm, which can be used as an analytical absorption band for the quantitative determination by absorption spectrophotometry. It has been proven that excipients do not interfere with the quantitative determination of the total amount of phenolic compounds in the composition of tablets with a dry extract of ginger since they do not absorb electromagnetic radiation in the region of the analytical maximum. It has been found that the content of the total amount of phenolic compounds calculated with reference to 6-gingerol in the experimental batch of tablets is 0.03556 ± 0.0088 g/tab. The relative uncertainty of the mean determination was 1.007 %. Conclusions . The spectrophotometric method for the quantitative determination of the total amount of phenolic compounds calculated with reference to 6-gingerol in tablets based on a dry ginger extract with the subsequent calculation by the standard method has been developed. It can be used to develop quality control procedures for the tablets under research.
建立了以干姜提取物为基础,以6-姜辣素为参照物的分光光度法测定片剂中酚类化合物含量的方法
采用分光光度法定量测定干姜浸膏片剂中6-姜辣素的总酚含量。研究平均g含有0.3 g的干提取物(制造商- Dnipro)通过直接压缩法获得。采用分光光度法测定酚类化合物,参照6-姜辣素计算。结果和讨论。研究了生姜生物活性酚类化合物中主要物质6-姜辣素标准样品的光谱特征。结果表明,其吸收光谱在220 ~ 400 nm范围内包含一个吸收带,最大吸收带在281 nm处,可作为吸收分光光度法定量测定的分析吸收带。由于辅料在分析最大值范围内不吸收电磁辐射,因此辅料不会干扰生姜干提取物片剂中酚类化合物总量的定量测定。经测定,以6-姜辣素为参照计算的实验批次片剂中酚类化合物的总含量为0.03556±0.0088 g/片。平均测定的相对不确定度为1.07%。结论。建立了以干姜提取物为基础,参照6-姜辣素计算片剂中酚类化合物总量的分光光度定量测定方法,并用标准方法进行计算。可用于制定所研究片剂的质量控制程序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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