Antioxidant and Anti-Osteosarcoma Effect of Edible Fungi Pleurotus ostreatus

Abstract

Osteosarcoma is a rare primary malignancy of bone and is extremely rare type, which accounts for about 0.2% of all cancer. It is treated with the advanced drugs which have effluent side effects when compared to the medicinal plants and phytoconstituents. The fundamental intention of this study is to study the antibacterial movement, phytochemical screening and anticancer action of ethanolic concentrate of Pleurotus ostreatus. The antimicrobial movement of Pleurotus ostreatus was recognized against two G -ve and two G +ve bacteria by agar well dissemination strategy. Based on the zone of inhibition formed the antimicrobial activity intensity were analyzed. The qualitative investigation of phytochemical screening was done which helps in analyzing the bioactive compounds present in the extract ethanolic and has demonstrated the nearness of flavonoids, terpenoids, alkaloids, saponins, starches, tannins, amino acids and steroids. The antioxidant test was done through DPPH and FRAP method. The invitro anticancer and cell toxicity of Pleurotus ostreatus against (osteosarcoma) human bone cancer cell lines compared to normal cell lines were premeditated. The anticancer test was experience against HL60 cancer cells of osteosarcoma. Subsequently, this investigation closes the ethanolic concentrate of Pleurotus ostreatus can be connected as a solid antimicrobial and anticancer properties.