The effects of spaceflight on mammary metabolism in pregnant rats.

K. Plaut, R. Maple, C. Vyas, S. Munaim, A. Darling, T. Casey, J. Alberts
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引用次数: 19

Abstract

The effects of spaceflight on mammary metabolism of 10 pregnant rats was measured on Day 20 of pregnancy and after parturition. Rats were flown on the space shuttle from Day 11 through Day 20 of pregnancy. After their return to earth, glucose oxidation to carbon dioxide increased 43% (P < 0.05), and incorporation into fatty acids increased 300% (P < 0.005) compared to controls. It is unclear whether the enhanced glucose use is due to spaceflight or a response to landing. Casein mRNA and gross histology were not altered at Day 20 of pregnancy. Six rats gave birth (on Day 22 to 23 of pregnancy) and mammary metabolic activity was measured immediately postpartum. The earlier effects of spaceflight were no longer apparent. There was also no difference in expression of beta-casein mRNA. It is clear from these studies that spaceflight does not impair the normal development of the mammary gland, its ability to use glucose, nor the ability to express mRNA for a major milk protein.
太空飞行对怀孕大鼠乳腺代谢的影响。
研究了航天飞行对10只妊娠大鼠妊娠第20天和分娩后乳腺代谢的影响。老鼠从怀孕的第11天到第20天乘坐航天飞机。返回地球后,与对照组相比,葡萄糖氧化为二氧化碳增加了43% (P < 0.05),转化为脂肪酸增加了300% (P < 0.005)。目前还不清楚葡萄糖消耗的增加是由于太空飞行还是对着陆的反应。妊娠第20天,酪蛋白mRNA和大体组织学没有改变。6只大鼠分娩(妊娠第22 ~ 23天),产后立即测量乳腺代谢活动。太空飞行的早期影响已不再明显。β -酪蛋白mRNA的表达也无差异。从这些研究中可以清楚地看出,太空飞行不会损害乳腺的正常发育、其利用葡萄糖的能力,也不会损害一种主要乳蛋白mRNA的表达能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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