Experimental analysis and optimization of synthesized magnetic nanoparticles coated with PMAMPC-MNPs for bioengineering application

Abstract

Biomedical and biotechnological engineering applications of magnetic nanoparticles (MNPs) for sensors are found to be of great importance. MNPs have attracted a growing interest in the design and development of sensors and biosensors for other several fields of applications. This research dealt with a novel optimization of MNPs of precipitation method of Fe³⁺ in basic solution. Also, for a surface coat with a random poly [(methacrylic acid)-ran-(2-methacryloyloxyethyl phosphorylcholine)] (PMAMPC-MNPs) by the means of chelating carboxylic group in its structure. We proposed MNPs to be incorporated into the transducer materials used for (bio)sensor and be dispersed in the sample. These caused an attraction by an external magnetic field onto the active detection surface of the (bio)sensor. RPM AMD PC and iron atoms were used to find the optimum conditions needed to coat the surfaces of the sensor such as particle concentrations. Particle technique FT-IR and TEM techniques showed that the synthesized PMAMPC-MNPs were spherical in shape in the range of 10–60 nm coated with a polymer capable of enhancing dispersion and good stability. In addition, particles coated with polymers of this property remain stable as the catalysts in reactions allowed the colour changes. This would be able to enhance sensitivity and stability of sensors and biosensors. This can be applied to the PMAMPC-MNPs for biosensors measurement application.