{"title":"Level of alpha dicarbonyl compound (methylglyoxal, diacetyl and glyoxal) in a sample of Iraqi patient with type 2 diabetic retinopathy","authors":"H. Hamid, E. Alwasiti, I. Al-Karawi","doi":"10.36295/ASRO.2021.24535","DOIUrl":null,"url":null,"abstract":"Diabetes mellitus is a common endocrine and metabolic diseases leading to impaired metabolism of carbohydrate, lipid, and protein. Hyperglycemiacoused by complete or relative insulin deficiency, insulin defective secretion and incorrect action. Diabetic retinopathy is characterized by microvascular lesions such as impaired blood flow regulation, increased vasopermeability, capillary basement membrane thickening, microaneurysm formation, capillary dropout, and eventually widespread nonperfusion and ischemia . Dicarbonyl stress is a dysfunctional state where methylglyoxal (MGO) and other reactive alpha-oxaldehyde metabolites accumulate as consequence of their increased formation or decreased activity of the detoxifying systems. In diabetic patients, MGO and MGO-related advanced end products (AGEs) are responsible for many diabetes-related complications.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":"8 1","pages":"431-437"},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Tropical Medicine and Public Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36295/ASRO.2021.24535","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetes mellitus is a common endocrine and metabolic diseases leading to impaired metabolism of carbohydrate, lipid, and protein. Hyperglycemiacoused by complete or relative insulin deficiency, insulin defective secretion and incorrect action. Diabetic retinopathy is characterized by microvascular lesions such as impaired blood flow regulation, increased vasopermeability, capillary basement membrane thickening, microaneurysm formation, capillary dropout, and eventually widespread nonperfusion and ischemia . Dicarbonyl stress is a dysfunctional state where methylglyoxal (MGO) and other reactive alpha-oxaldehyde metabolites accumulate as consequence of their increased formation or decreased activity of the detoxifying systems. In diabetic patients, MGO and MGO-related advanced end products (AGEs) are responsible for many diabetes-related complications.