Level of alpha dicarbonyl compound (methylglyoxal, diacetyl and glyoxal) in a sample of Iraqi patient with type 2 diabetic retinopathy

H. Hamid, E. Alwasiti, I. Al-Karawi
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Abstract

Diabetes mellitus is a common endocrine and metabolic diseases leading to impaired metabolism of carbohydrate, lipid, and protein. Hyperglycemiacoused by complete or relative insulin deficiency, insulin defective secretion and incorrect action. Diabetic retinopathy is characterized by microvascular lesions such as impaired blood flow regulation, increased vasopermeability, capillary basement membrane thickening, microaneurysm formation, capillary dropout, and eventually widespread nonperfusion and ischemia . Dicarbonyl stress is a dysfunctional state where methylglyoxal (MGO) and other reactive alpha-oxaldehyde metabolites accumulate as consequence of their increased formation or decreased activity of the detoxifying systems. In diabetic patients, MGO and MGO-related advanced end products (AGEs) are responsible for many diabetes-related complications.
伊拉克2型糖尿病视网膜病变患者样本中α二羰基化合物(甲基乙二醛、二乙酰基和乙二醛)的水平
糖尿病是一种常见的内分泌和代谢疾病,导致碳水化合物、脂质和蛋白质的代谢受损。由完全或相对胰岛素缺乏、胰岛素分泌缺陷和不正确的动作引起的高血糖。糖尿病视网膜病变的特征是微血管病变,如血流调节功能受损、血管通透性增加、毛细血管基底膜增厚、微动脉瘤形成、毛细血管脱落,最终出现广泛的非灌注和缺血。二羰基应激是一种功能失调状态,其中甲基乙二醛(MGO)和其他活性α -氧醛代谢物由于其解毒系统的形成增加或活性降低而积累。在糖尿病患者中,MGO和MGO相关的晚期终产物(AGEs)是导致许多糖尿病相关并发症的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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