Rapid Progression of Sternocostoclavicular Hyperostosis (SCCH) Observed after Anti-TNF-a Therapy for Polyarthritis: A Case Report

Abstract

Sternocostoclavicular hyperostosis (SCCH) is a chronic osssifying diathesis affecting mostly juxtasternal structures and the inflammatory osteitis is mostly part of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. we presented a case of 62-year-old woman with polyarthritis in bilateral hands, who had experienced swelling of anterior chest wall sinse she was 30 years old. we decided to treat her with an anti-TNF α antibody biologics, golimumab, after failure of conventional disease-modifying antirheumatic drugs (Cs DMARDs). Although clinical remisson had been successfuly induced, rapid progression of SCCH and skin menifestation were confirmed without recurrence of the peripheral arthritis. Results of the bone biopsy and the culture study indicated the relapse of SCCH was not caused by infection or neoplasma and, postoperatively, the chest pain was gradually decreased and along with an improvement of the skin erruption.