Predicting antipsychotic-induced weight gain in first episode psychosis-a protocol for a field-wide systematic review of prognostic factor studies

Ita Fitzgerald, Erin K. Crowley, Amy Byrne, J. O’Connell, J. Ensor, Ciara Ní Dhubhlaing, S. O’Dwyer, L. Sahm
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引用次数: 1

Abstract

Background: One significant complexity associated with management of antipsychotic-induced weight gain (AIWG) is extensive interindividual variability amongst patients in initial susceptibility to AIWG, time to plateau of weight gain, and resultant final amount of weight gained. Prior to antipsychotic commencement, risk-stratified information highlighting those at increased risk of experiencing significant AIWG would allow tailored weight monitoring and subsequent management protocols to be developed.Methods: This protocol is for a planned systematic review to identify the current utility of baseline clinical, sociodemographic, and biological prognostic factors in predicting the likelihood of significant AIWG occurring prior to antipsychotic commencement. The cohort assessed will be antipsychotic-naïve adults with a first episode of psychosis. Searches for both randomised and prospective non-randomised studies will be undertaken by searching four electronic databases and two trial registers, followed by reference searching, forward citation searching and liaison with content experts. A meta-analysis of study results will be undertaken where study quality and homogeneity allow. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework modified for prognostic research will be used to assess evidence certainty. This protocol was prepared in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols guideline and latest guidance from the Prognosis Methods Group of the Cochrane Collaboration.Results: This review will establish the current quantity, quality and clinical utility of evidence addressing the prognostic association of clinical, biological, and sociodemographic factors in prospectively identifying those more likely to experience significant AIWG.Registration details: PROSPERO registration number CRD42021258148.
预测首发精神病患者抗精神病药物引起的体重增加——一项对预后因素研究的全领域系统回顾的方案
背景:与抗精神病药致体重增加(AIWG)管理相关的一个重要复杂性是,患者对AIWG的初始易感性、体重增加达到平台期的时间以及最终体重增加的量存在广泛的个体差异。在开始使用抗精神病药物之前,风险分层信息强调了那些经历显著AIWG的风险增加的人,这将允许制定量身定制的体重监测和随后的管理方案。方法:本方案是一项有计划的系统评价,以确定基线临床、社会人口统计学和生物学预后因素在预测抗精神病药物开始前发生显著AIWG可能性方面的当前效用。评估的队列将是antipsychotic-naïve首发精神病的成年人。随机和前瞻性非随机研究的检索将通过检索四个电子数据库和两个试验注册库进行,随后进行参考文献检索、引文转发检索和与内容专家联系。在研究质量和同质性允许的情况下,对研究结果进行荟萃分析。针对预后研究修改的建议分级、评估、发展和评价(GRADE)框架将用于评估证据的确定性。本方案是根据系统评价和荟萃分析首选报告项目(PRISMA)方案指南和Cochrane协作组织预后方法组的最新指南编写的。结果:本综述将建立目前的数量、质量和临床应用证据,探讨临床、生物学和社会人口因素与预后的关联,以前瞻性地识别那些更可能经历显著AIWG的患者。注册详情:普洛斯彼罗注册号CRD42021258148。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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