Fospropofol Disodium Injection: A Review of its Use as a Sedative-hypnotic Agent for Monitored Anesthesia Care (MAC) Sedation in Adult Patients Undergoing Diagnostic or Therapeutic Procedures:

E. Harris, D. Lubarsky, K. Candiotti
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Abstract

Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/BIS suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug’s administration. Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.
氟丙酚二钠注射液:在诊断或治疗过程中作为麻醉监护(MAC)镇静催眠剂的应用综述
磷酸异丙酚是常用诱导剂异丙酚的前药磷酸化版本,在体内水解释放活性异丙酚、甲醛和磷酸盐。药效学研究表明,磷异丙酚提供临床有用的镇静和脑电图/BIS抑制,同时引起的呼吸抑制明显少于丙泊酚。注射部位疼痛是异丙酚的常见主诉,但在异丙酚中没有报告;患者的主要主诉为用药期间短暂性肛周瘙痒。尽管许多临床医生认为,由注册护士给药是安全的,但FDA规定,像异丙酚一样,只有在训练有素的麻醉师在场的情况下才能使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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