Molecularly imprinted composite polymers based on trimethylolpropane trimethacrylate (TRIM) particles for efficient enantiomeric separations

Reactive Polymers Pub Date : 1995-05-01 DOI:10.1016/0923-1137(95)00018-E

Magnus Glad , Per Reinholdsson , Klaus Mosbach

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引用次数: 72

Abstract

A convenient method to prepare spherical microparticulate composite adsorbents is described. Molecularly imprinted crosslinked methacrylate polymers were copolymerized with preformed microparticulate support particles of trimethylolpropane trimethacrylate (TRIM) containing residual double bonds. The resulting composite adsorbent could be packed in HPLC columns after just a simple washing procedure and was used for efficient chiral separation of amino acid derivatives. The pore system of the TRIM-particles could be filled with large amounts of functional polymer. The enantioselectivity for the print molecule Boc-L-Phe-OH was in the same range as that obtained by traditional bulk phase molecular imprinting, while the performance in HPLC was improved, both in terms of efficiency and pressure stability. The effect of various degrees of crosslinking and of monomer concentration on polymer characteristics, such as porosity and specific surface area, and its impact on the structure of the final polymer is discussed as well as the chromatographic performance of the resulting matrices.

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基于三甲基丙烷三甲基丙烯酸酯(TRIM)颗粒的分子印迹复合聚合物，用于有效的对映体分离

介绍了一种制备球形微颗粒复合吸附剂的简便方法。将分子印迹交联的甲基丙烯酸酯聚合物与预成型的含有残余双键的三甲基丙烯三甲基丙烯酸酯(TRIM)微粒载体颗粒共聚。所制备的复合吸附剂只需经过简单的洗涤即可装在高效液相色谱柱中，用于氨基酸衍生物的高效手性分离。trimm颗粒的孔隙系统可以被大量的功能聚合物填充。打印分子boc - l - pheoh的对映选择性与传统体相分子印迹的对映选择性在同一范围内，同时在高效液相色谱中效率和压力稳定性均有提高。讨论了不同程度的交联和单体浓度对聚合物特性的影响，如孔隙率和比表面积，及其对最终聚合物结构的影响，以及所得基质的色谱性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reactive Polymers

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