Progress and prospects of nanocomposite hydrogels in bone tissue engineering

IF 4.2 3区材料科学 Q2 MATERIALS SCIENCE, COMPOSITES

Nanocomposites Pub Date : 2022-05-10 DOI:10.1080/20550324.2022.2076025

C. Du, Wei Huang

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引用次数: 9

Abstract

Abstract Hydrogels are hydrophilic polymers with high flexibility and elasticity, and are widely used in the field of bone tissue engineering. However, their low toughness and insufficient mechanical strength have limited their applications. Nanocomposite hydrogels are flexible and porous as well as possess excellent biocompatibility and mechanical strength, thus exhibiting a significant potential to be used in the field of bone tissue engineering. Nanocomposite hydrogels are synthesized by chemically or physically crosslinking nanomaterials and hydrogels, and their physical, chemical, and biological properties can be enhanced by changing the properties and compositions of the nanomaterials. Both nanomaterials and hydrogel polymers can be customized, and therefore, nanocomposite hydrogels can be developed for bone repair under different conditions. In this review, we first introduce the synthesis methods and properties of nanocomposite hydrogels, and then summarize the applications and progress of nanocomposite hydrogels in bone tissue engineering. Graphical Abstract Nanocomposite hydrogels are used in bone tissue engineering. Adapted from Huang et al. (2019) [121]

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纳米复合水凝胶在骨组织工程中的研究进展与展望

摘要水凝胶是一种具有高柔韧性和弹性的亲水性聚合物，在骨组织工程领域有着广泛的应用。但其韧性低，机械强度不足，限制了其应用。纳米复合水凝胶具有柔韧性和多孔性，具有良好的生物相容性和机械强度，在骨组织工程领域具有很大的应用潜力。纳米复合水凝胶是将纳米材料与水凝胶进行化学或物理交联而合成的，通过改变纳米材料的性质和组成可以增强其物理、化学和生物性能。纳米材料和水凝胶聚合物都可以定制，因此，纳米复合水凝胶可以用于不同条件下的骨修复。本文首先介绍了纳米复合水凝胶的合成方法和性能，然后综述了纳米复合水凝胶在骨组织工程中的应用和进展。纳米复合水凝胶在骨组织工程中的应用。改编自黄等人(2019)[121]

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来源期刊

Nanocomposites Multiple-

CiteScore

7.40

自引率

15.20%

发文量

审稿时长

16 weeks