Relationship between Gastric Cancers and Trio of Helicobacter Pylori Infection, Chronic Gastritis and Gastric Mucosal Intestinal Metaplasia as seen in Jos University Teaching Hospital, Nigeria

Abstract

Background: In 1994 Helicobacter pylori was classified as class 1 human carcinogen by the IARC (WHO), based on epidemiological evidence. Experimental evidence was subsequently provided by Wantabe et al. This has triggered several studies on the prevalence of H. pylori in patients with Gastric cancers in various regions of the world. In Africa the infection rate in various populations as reported by some studies are not parallel to the incidence of morbidity caused by this infection. Objective: To determine the relationship between Helicobacter pylori infection, Chronic gastritis, Gastric mucosal intestinal metaplasia with Gastric cancers. Methodology: This was a retrospective histopathological study of all gastric cancers with adjacent non – cancerous epithelium seen between January 2005 and December 2012 in the department of Histopathology, Jos University Teaching Hospital (JUTH). Blocks and archival slides were used for the