The Prevalence and Pattern of Enterobacter Antibiotic Resistance in the Patients Admitted to Imam Reza Hospital in Kermanshah, Iran (2016 - 2018)

Zeinab Mohseni Afshar, R. Miladi, A. Janbakhsh, F. Mansouri, B. Sayad, S. Vaziri, M. Afsharian, M. Zamanian, M. Shirvani, S. Yavari, Mitra Tarlan, S. Khazaei
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引用次数: 2

Abstract

Background: Antibiotic resistance is spreading worldwide against the Gram-negative bacteria that cause nosocomial infections. Objectives: The present study aimed to determine the antibiotic resistance pattern of Enterobacter isolated from the blood, urine, wound, and sputum samples of the patients referring to Imam Reza Hospital in Kermanshah, Iran. Methods: This descriptive, cross-sectional study was conducted on 649 patients with positive Enterobacter cultures at Imam Reza Hospital during 2016 - 2018. The isolates were obtained using laboratory tests based on the CLSI protocol. In addition, the standard disc-diffusion method was used to assess antibiotic susceptibility. Data analysis was performed in SPSS version 20. Results: Most cases of positive Enterobacteriaceae were isolated from the patients admitted to the intensive care unit (35.6%) and emergency ward (21.9%), as well as the urine (51.6%) and sputum samples (20.5%), respectively. Levofloxacin, ciprofloxacin, and imipenem were the most effective antibiotics against Enterobacter with the susceptibility of 56.7%, 54.8%, and 53.3%, respectively. Conclusions: According to the results, the antibiotic resistance of Enterobacter to ampicillin and ceftriaxone was high, and these antibiotics must be used correctly and reasonably. Furthermore, more epidemiological studies are required in Iran to provide national programs for preventing the spread of antibiotic resistance.
2016 - 2018年伊朗克尔曼沙阿伊玛目礼萨医院住院患者肠杆菌耐药情况及模式分析
背景:针对引起医院感染的革兰氏阴性菌的抗生素耐药性正在世界范围内蔓延。目的:本研究旨在确定在伊朗克尔曼沙阿伊玛目礼萨医院就诊的患者的血液、尿液、伤口和痰中分离的肠杆菌的抗生素耐药模式。方法:对2016 - 2018年伊玛目礼萨医院649例肠杆菌培养阳性患者进行描述性横断面研究。分离物采用基于CLSI协议的实验室检测获得。此外,采用标准的纸片扩散法评估抗生素敏感性。数据分析采用SPSS version 20。结果:肠杆菌科阳性病例以重症监护病房(35.6%)、急诊病房(21.9%)、尿液(51.6%)和痰液(20.5%)检出最多。左氧氟沙星、环丙沙星和亚胺培南对肠杆菌的敏感性最高,分别为56.7%、54.8%和53.3%。结论:根据结果,肠杆菌对氨苄西林和头孢曲松耐药较高,应正确合理使用。此外,伊朗需要进行更多的流行病学研究,以提供防止抗生素耐药性传播的国家规划。
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