Solitary fibrous tumor of the tongue

Kei Sakamoto , Toshihiro Sawai , Akira Yamaguchi
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引用次数: 17

Abstract

A rare case of solitary fibrous tumor occurring in the tongue is described. An 80-year old woman presented with a slow-growing painless mass in the apex of the tongue. Under a clinical diagnosis of benign tongue tumor, surgical excision was performed. The tumor was a submucosal well-demarcated mass of two centimeters in diameter. Microscopically, spindle-shaped tumor cells were haphazardly arranged in sheets, fascicles or whirling patterns with thick collagen bundles and marked capillary proliferation. Immunohistochemically, tumor cells were positive for vimentin, CD34 and Bcl-2, but negative for EMA, CD99 and S-100. Some tumor cells were positive for smooth muscle actin and also for angiogenic factors, such as VEGF, bFGF and their receptors, suggesting strong inclination to angiogenic differentiation. Although the tumor showed few signs of malignancy, a high labeling index of p53 was noted, implying a potential for malignant transformation.

舌上孤立的纤维性肿瘤
一个罕见的病例孤立的纤维性肿瘤发生在舌头。一个80岁的妇女提出了一个缓慢增长的无痛肿块在舌尖。经临床诊断为舌良性肿瘤,施行手术切除。肿瘤为黏膜下清晰的肿块,直径2厘米。镜下,梭形肿瘤细胞呈片状、束状或旋涡状排列,胶原束粗大,毛细血管增生明显。免疫组化结果显示,肿瘤细胞vimentin、CD34、Bcl-2阳性,EMA、CD99、S-100阴性。部分肿瘤细胞平滑肌肌动蛋白阳性,血管生成因子如VEGF、bFGF及其受体阳性,提示血管生成分化倾向强。虽然肿瘤几乎没有恶性肿瘤的迹象,但p53的高标记指数被注意到,这意味着可能发生恶性转化。
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