Modelling columnarity of pyramidal cells in the human cerebral cortex

IF 0.8 4区 数学 Q3 STATISTICS & PROBABILITY
Andreas Dyreborg Christoffersen, Jesper M⊘ller, Heidi S⊘gaard Christensen
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引用次数: 7

Abstract

For modelling the location of pyramidal cells in the human cerebral cortex, we suggest a hierarchical point process in that exhibits anisotropy in the form of cylinders extending along the z-axis. The model consists first of a generalised shot noise Cox process for the xy-coordinates, providing cylindrical clusters, and next of a Markov random field model for the z-coordinates conditioned on the xy-coordinates, providing either repulsion, aggregation or both within specified areas of interaction. Several cases of these hierarchical point processes are fitted to two pyramidal cell data sets, and of these a final model allowing for both repulsion and attraction between the points seem adequate. We discuss how the final model relates to the so-called minicolumn hypothesis in neuroscience.

模拟人类大脑皮层锥体细胞的柱状结构
为了模拟人类大脑皮层中锥体细胞的位置,我们提出了一个分层点过程,该过程以沿z轴延伸的圆柱体形式表现出各向异性。该模型首先由xy坐标的广义射击噪声Cox过程组成,提供圆柱形簇,然后是基于xy坐标的z坐标的马尔可夫随机场模型,在指定的相互作用区域内提供排斥,聚集或两者。这些分层点过程的几个案例被拟合到两个金字塔细胞数据集上,并且这些最终模型允许点之间的排斥和吸引似乎是足够的。我们将讨论最终模型如何与神经科学中所谓的小柱假说相关联。
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来源期刊
Australian & New Zealand Journal of Statistics
Australian & New Zealand Journal of Statistics 数学-统计学与概率论
CiteScore
1.30
自引率
9.10%
发文量
31
审稿时长
>12 weeks
期刊介绍: The Australian & New Zealand Journal of Statistics is an international journal managed jointly by the Statistical Society of Australia and the New Zealand Statistical Association. Its purpose is to report significant and novel contributions in statistics, ranging across articles on statistical theory, methodology, applications and computing. The journal has a particular focus on statistical techniques that can be readily applied to real-world problems, and on application papers with an Australasian emphasis. Outstanding articles submitted to the journal may be selected as Discussion Papers, to be read at a meeting of either the Statistical Society of Australia or the New Zealand Statistical Association. The main body of the journal is divided into three sections. The Theory and Methods Section publishes papers containing original contributions to the theory and methodology of statistics, econometrics and probability, and seeks papers motivated by a real problem and which demonstrate the proposed theory or methodology in that situation. There is a strong preference for papers motivated by, and illustrated with, real data. The Applications Section publishes papers demonstrating applications of statistical techniques to problems faced by users of statistics in the sciences, government and industry. A particular focus is the application of newly developed statistical methodology to real data and the demonstration of better use of established statistical methodology in an area of application. It seeks to aid teachers of statistics by placing statistical methods in context. The Statistical Computing Section publishes papers containing new algorithms, code snippets, or software descriptions (for open source software only) which enhance the field through the application of computing. Preference is given to papers featuring publically available code and/or data, and to those motivated by statistical methods for practical problems.
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