Biomarkers associated with early detection of aging in human: a review

YMER Digital Pub Date : 2022-08-19 DOI:10.37896/ymer21.08/61
Aishi Bera, Preeti Roy
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Abstract

Most chronic illnesses as well as functional deficits happen to be exacerbated by aging. There happens to be an existing significant heterogeneity inside of the level that belongs to illness as well as functional impairment risk within an existing homogenous age group, highlighting the need that is going to belong to appropriate biomarkers to help inside of describing the complicated aging processes. The diversity that belongs to biological living environments, lifestyle activities, as well as medical treatments complicates the discovery that belongs to biomarkers even further. During the same time as an existing result, no one biomarker or gold standard instrument that is going to belong to monitoring effective or healthy aging has been identified. The current state that belongs to knowledge on top of possible biomarkers happens to be described inside of this brief overview, with an existing emphasis on top of their application to the primary physiological systems influenced by the aging process, such during the same time that physical capacity, nutritional status, body composition, as well as endocrine as well as immunological function. Keywords - Biomarkers, Aging, MARK-AGE consortium, biomarkers of different human organ systems, frailty syndrome biomarker, DNA methylation biomarker, Phenotypic biomarker, Genetic biomarker, Immunological biomarker, Cellular biomarker, Deep - Aging clocks
与人类衰老早期检测相关的生物标志物:综述
大多数慢性疾病和功能缺陷都会随着年龄的增长而加剧。在现有的同质年龄组中,疾病和功能损伤风险的水平恰好存在显著的异质性,这突出了需要适当的生物标志物来帮助描述复杂的衰老过程。生物生活环境、生活方式活动以及医学治疗的多样性使生物标志物的发现更加复杂。与此同时,作为现有的结果,没有一种生物标志物或金标准仪器将属于监测有效或健康衰老。在这篇简短的概述中,恰好描述了目前属于可能的生物标志物之上的知识的状态,现有的重点是它们在受衰老过程影响的主要生理系统中的应用,例如与此同时,身体能力,营养状况,身体成分,以及内分泌和免疫功能。关键词:生物标志物,衰老,MARK-AGE联盟,不同人体器官系统的生物标志物,脆弱综合征生物标志物,DNA甲基化生物标志物,表型生物标志物,遗传生物标志物,免疫学生物标志物,细胞生物标志物,深度衰老时钟
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