Relationship between apolipoprotein E gene polymorphism and cerebral infraction in Chinese type 2 diabetes mellitus patients

Abstract

Objective To investigate the relationship between apolipoprotein E (APOE) gene polymorphism and cerebral infraction (CI) in Chinese type 2 diabetes mellitus (T2DM) patients. Methods This study included 245 samples of T2DM patients without cerebral infraction (CON group) (Male/Female, 128/117) and 270 samples of T2DM patients with cerebral infraction (CI group)(Male/Female, 145/125) from the department of endocrinology and neurology utilizing real-time fluorescence quantitative PCR technique. The t test and χ2 test were used to compare the differences between the two groups. Results Patients with a history of hypertension in the CI group (84.12%) were significantly higher than those in the CON group (70.42%) (χ2=15.91, P<0.05).The systolic blood pressure (142.78±20.52)mmHg of the CI group was significantly higher than that of the CON group (133.89±18.58)mmHg (t=-5.16, P<0.05).Compared with CON group, the frequency of genotypes of e2/e3 and e3/e4 in CI group was significantly higher, while the frequency of e3/e3 genotype was significantly lower (χ2=11.48, P<0.05); the allele frequency of APOE e4 was higher while e3 was lower in CI group than that in CON group (χ2=7.00, P<0.05). Logistic regression analysis showed that hypertension history (OR=1.95, P<0.05), high systolic blood pressure (OR=1.02, P<0.05), APOE genotypes of e2/e3 (OR=2.08, P<0.05) and e3/e4 (OR=1.85, P<0.05) were independent risk factors for cerebral infarction in T2DM patients. Conclusion The polymorphism of APOE gene may be related to cerebral infraction in Chinese T2DM patients. Key words: Diabetes mellitus, type 2; Diabetic angiopathies; Brain infarction; Apolipoprotein E4; Polymorphism, genetic