Synergic fabrication of hybrid nanocapsules gold-organosilica for MRI-guided photothermal-enhanced synergistic effect chemodynamic lung cancer therapy

Journal of Macromolecular Science, Part A Pub Date : 2023-05-31 DOI:10.1080/10601325.2023.2212732

Dongdong Wang, Na Xu, Yang Guo, Dan Wang, Yongzhong Liang

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Abstract

Abstract In contrast to the typical template-based multistep approach for constructing multi-functional mesoporous hollow silica nanocomposites (MHSN), a simple and template-free fabricate system has been developed to develop versatile mesoporous hollow silica nanocapsules (OSNs) encompassing together isopentyl acetate (IsA) solution and AuNPs. This new material has tiny and homogeneous particle sizes (∼82 nm), a large surface area (535 m2 g−1), and remarkable colloidal durability in water. The oil-phase IsA with high volatility and a low boiling point (142 °C) is critical in building bulky hollow cavities from structural strategy. It allows the IsA@OSNs to become an effective development mediator in the ablation of high-intensity focused ultrasound (HIFU) treatment. Furthermore, the distinctive satellite-like dispersion of Gold (AuNPs) on the silica shell provided IsA@OSNs with outstanding magnetic resonance imaging (MRI) contrasts in A549 lung cells in vitro and in vivo. Furthermore, such unique theranostics agents have excellent systemic toxicity, which promises well for promising clinical use in MRI-piloted HIFU treatment. Graphical Abstract

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协同制备金-有机二氧化硅杂化纳米胶囊用于mri引导光热增强协同效应化疗肺癌治疗

摘要:与典型的基于模板的多步骤构建多功能介孔中空二氧化硅纳米复合材料(MHSN)的方法不同，我们开发了一种简单且无模板的制备体系，用于制备多功能介孔中空二氧化硅纳米胶囊(OSNs)，其中包括乙酸异戊酯(IsA)溶液和AuNPs。这种新材料具有微小且均匀的颗粒尺寸(~ 82 nm)，大表面积(535 m2 g−1)，以及在水中显着的胶体耐久性。具有高挥发性和低沸点(142°C)的油相IsA对于从结构策略构建大体积空心腔至关重要。它允许IsA@OSNs成为高强度聚焦超声(HIFU)治疗消融术中有效的发育介质。此外，二氧化硅外壳上独特的卫星状金(AuNPs)弥散为IsA@OSNs在体外和体内的A549肺细胞提供了出色的磁共振成像(MRI)对比。此外，这种独特的治疗药物具有良好的全身毒性，在mri引导的HIFU治疗中有很好的临床应用前景。图形抽象

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Journal of Macromolecular Science, Part A

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