Predicting fibrosis progression in non-alcoholic fatty liver disease patients using the FAST Score: A paired biopsy study.

IF 2.8 3区 地球科学 Q3 METEOROLOGY & ATMOSPHERIC SCIENCES
Monthly Weather Review Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI:10.14744/hf.2023.2023.0021
Nisanur Sariyar, Haluk Tarik Kani, Cigdem Ataizi Celikel, Yusuf Yilmaz
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引用次数: 0

Abstract

Background and aim: This study aimed to investigate the predictive value of various non-invasive scores for identifying the progression of hepatic fibrosis over time in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).

Materials and methods: We examined 69 patients with NAFLD who had undergone two liver biopsies at an average interval of 21.3±9.7 months. Progression and regression of fibrosis were defined as an increase or decrease of at least one stage in fibrosis between the initial and follow-up biopsies, respectively. The Fibrosis-4 Index (FIB-4), NAFLD Fibrosis Score (NFS), Agile 3+, Agile 4, and FibroScan-AST (FAST) scores were calculated at the initial biopsy.

Results: Comparison of paired biopsies revealed that 45% of participants (n=31) exhibited no change in fibrosis stages, 26% (n=18) experienced progression, and 29% (n=20) demonstrated regression. Multivariable logistic regression analysis identified the FAST score as the only independent predictor of progressive fibrosis, with the odds increasing by 19% (95% CI: 8-38%, p<0.05) for each unit increase in the FAST score at the initial biopsy. No independent predictors for fibrosis regression were identified.

Conclusion: Higher baseline FAST scores were associated with an increased likelihood of fibrosis progression, independent of other variables. Thus, the FAST score could serve as both a diagnostic and prognostic tool for fibrosis in patients with NAFLD.

使用 FAST 评分预测非酒精性脂肪肝患者的纤维化进展:配对活检研究
背景和目的:本研究旨在探讨各种非侵入性评分对识别非酒精性脂肪肝(NAFLD)患者肝纤维化随时间进展的预测价值:我们对 69 名非酒精性脂肪肝患者进行了检查,这些患者平均间隔 21.3±9.7 个月接受了两次肝活检。纤维化的进展和消退分别定义为初次活检和随访活检之间纤维化至少增加或减少一个阶段。在初次活检时计算纤维化-4指数(FIB-4)、非酒精性脂肪肝纤维化评分(NFS)、Agile 3+、Agile 4和FibroScan-AST(FAST)评分:对配对活检结果进行比较后发现,45% 的参与者(31 人)的纤维化程度没有变化,26% 的参与者(18 人)的纤维化程度有所进展,29% 的参与者(20 人)的纤维化程度有所下降。多变量逻辑回归分析表明,FAST评分是纤维化进展的唯一独立预测因子,其几率增加了19%(95% CI:8-38%,p结论:基线FAST评分越高,纤维化进展的可能性越大,这与其他变量无关。因此,FAST评分可作为非酒精性脂肪肝患者纤维化的诊断和预后工具。
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来源期刊
Monthly Weather Review
Monthly Weather Review 地学-气象与大气科学
CiteScore
6.40
自引率
12.50%
发文量
186
审稿时长
3-6 weeks
期刊介绍: Monthly Weather Review (MWR) (ISSN: 0027-0644; eISSN: 1520-0493) publishes research relevant to the analysis and prediction of observed atmospheric circulations and physics, including technique development, data assimilation, model validation, and relevant case studies. This research includes numerical and data assimilation techniques that apply to the atmosphere and/or ocean environments. MWR also addresses phenomena having seasonal and subseasonal time scales.
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