Electrochemical Determination of Anesthetic Drug Ropivacaine in Pharmaceutical Formulations by Differential Pulse Cathodic Adsorptive Stripping Voltammetry

Abstract

Electrochemical behaviour of ropivacaine at glassy carbon electrode was studied by cyclic and differential pulse cathodic adsorptive stripping voltammetry (DPCAdSV) under different experimental conditions. The voltammetric peak current and potential for the reduction of ropivacaine were analyzed at different pH, scan rate and concentration. The voltammograms exhibited irreversible reduction of ropivacaine in B.R. buffer of pH 9. The proposed method was successfully applied for the determination of the drug which is commercial liquid. The proposed differential pulse cathodic adsorptive stripping voltammetric method shows limit of detection (LOD) and limit of quantification (LOQ) are 7.79×10 g/mL and 4.26×10 g/mL respectively.