Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population

IF 1.1 4区生物学 Q4 GENETICS & HEREDITY

Mitochondrial Dna Part a Pub Date : 2018-01-02 DOI:10.1080/24701394.2016.1233530

H. Charoute, R. Kefi, Safaa Bounaceur, H. Benrahma, A. Reguig, M. Kandil, H. Rouba, A. Bakhchane, S. Abdelhak, A. Barakat

引用次数: 7

Abstract

Abstract In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher’s exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (p = .02) and C16320T (p = .03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.

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摩洛哥人群中与2型糖尿病相关的线粒体DNA新变异

在这项研究中，我们研究了摩洛哥患者mtDNA变异和单倍群与2型糖尿病(T2D)的关系。对108例糖尿病患者和97例对照者的mtDNA高变段1进行了测序。采用Fisher精确检验和多元逻辑回归进行关联分析。5种mtDNA变异(C16187T、C16270T、T16172C、A16293G和C16320T)在病例中的患病率显著高于对照组。在这些变异中，经年龄和性别调整后，只有C16270T (p = 0.02)和C16320T (p = 0.03)仍然显著。我们发现C16270T和C16320T变异与摩洛哥患者T2D风险增加密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrial Dna Part a Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： Mitochondrial DNA Part A publishes original high-quality manuscripts on physical, chemical, and biochemical aspects of mtDNA and proteins involved in mtDNA metabolism, and/or interactions. Manuscripts on cytosolic and extracellular mtDNA, and on dysfunction caused by alterations in mtDNA integrity as well as methodological papers detailing novel approaches for mtDNA manipulation in vitro and in vivo are welcome. Descriptive papers on DNA sequences from mitochondrial genomes, and also analytical papers in the areas of population genetics, phylogenetics and human evolution that use mitochondrial DNA as a source of evidence for studies will be considered for publication. The Journal also considers manuscripts that examine population genetic and systematic theory that specifically address the use of mitochondrial DNA sequences, as well as papers that discuss the utility of mitochondrial DNA information in medical studies and in human evolutionary biology.