Masahiko Takahashi, M. Kikuchi, H. Ebinuma, H. Saito
{"title":"Nutritional status and body composition dynamics with peginterferon alpha and ribavirin combination therapy in chronic hepatitis C patients","authors":"Masahiko Takahashi, M. Kikuchi, H. Ebinuma, H. Saito","doi":"10.3923/IJV.2015.12.19","DOIUrl":null,"url":null,"abstract":"Weight loss has been reported in patients treated with peginterferon alpha (Peg-IFN-\") and ribavirin, however, the pathophysiological mechanism of this weight loss is unclear. We prospectively evaluated the nutritional status, body composition and dietary intake of 10 chronic hepatitis C patients treated with Peg-IFN-\" and ribavirin, before, at the end of and at 6 months after treatment. Nutritional status and body composition were evaluated by using anthropometric analyses and Bioelectrical Impedance Analysis (BIA) with a body composition analyzer. Body weight, body mass index and total energy intake were significantly (p<0.05) reduced at the end of treatment compared with before treatment, however, at 6 months after treatment, they were recovered to before-treatment levels. In anthropometric analyses, percent Triceps Skinfold Thickness (TSF%) which represents body fat mass was significantly (p<0.05) decreased at the end of treatment compared with before treatment, whereas, percent Arm Muscle Circumference (AMC%) which represents body muscle was not. In the BIA, body fat mass was also significantly (p<0.05) decreased, whereas, skeletal muscle mass was not. There were no significant changes in grip strength and serum albumin level. Decreased TSF% and body fat mass were also recovered to before treatment values at 6 months after treatment. The body weight loss observed during Peg-IFN-\"-2b and ribavirin was attributable to body fat mass decrease rather than skeletal muscle mass decrease. Decreased body weight and decreased body fat mass were recovered to before treatment values at 6 months after treatment without body composition change.","PeriodicalId":14458,"journal":{"name":"International Journal of Virology and AIDS","volume":"27 1","pages":"12-19"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Virology and AIDS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3923/IJV.2015.12.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Weight loss has been reported in patients treated with peginterferon alpha (Peg-IFN-") and ribavirin, however, the pathophysiological mechanism of this weight loss is unclear. We prospectively evaluated the nutritional status, body composition and dietary intake of 10 chronic hepatitis C patients treated with Peg-IFN-" and ribavirin, before, at the end of and at 6 months after treatment. Nutritional status and body composition were evaluated by using anthropometric analyses and Bioelectrical Impedance Analysis (BIA) with a body composition analyzer. Body weight, body mass index and total energy intake were significantly (p<0.05) reduced at the end of treatment compared with before treatment, however, at 6 months after treatment, they were recovered to before-treatment levels. In anthropometric analyses, percent Triceps Skinfold Thickness (TSF%) which represents body fat mass was significantly (p<0.05) decreased at the end of treatment compared with before treatment, whereas, percent Arm Muscle Circumference (AMC%) which represents body muscle was not. In the BIA, body fat mass was also significantly (p<0.05) decreased, whereas, skeletal muscle mass was not. There were no significant changes in grip strength and serum albumin level. Decreased TSF% and body fat mass were also recovered to before treatment values at 6 months after treatment. The body weight loss observed during Peg-IFN-"-2b and ribavirin was attributable to body fat mass decrease rather than skeletal muscle mass decrease. Decreased body weight and decreased body fat mass were recovered to before treatment values at 6 months after treatment without body composition change.