Long-term benefit after allergen immunotherapy to HDM in elderly patients with allergic rhinitis.

IF 0.3 4区材料科学 Q4 MATERIALS SCIENCE, CHARACTERIZATION & TESTING

Powder Diffraction Pub Date : 2023-10-01 Epub Date: 2023-07-19 DOI:10.5114/ada.2023.129942

Andrzej Bożek, Agnieszka Bogacz-Piaseczyńska, Martyna Miodońska, Dominika Sadowska

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引用次数: 0

Abstract

Introduction: Allergen immunotherapy (AIT) is an effective therapy for allergic rhinitis and may have long-term benefits. However, these benefits have not been strictly defined for older people.

Aim: The evaluation of the effectiveness of AIT in patients over 60 with allergic rhinitis and house dust mites (HDM) allergy over a period of 7 years was performed.

Material and methods: Patients after three years of HDM-AIT were observed to assess the sustained clinical effect of treatment. The average adjusted symptom score (AAdSS) and sIgG4 were monitored for 7 years after sublingual (SLIT) and injection AIT (SCIT).

Results: After 3 years of HDM-AIT, a significant clinical effect was observed in the group after SLIT and SCIT based on AAdSS compared to the baseline and the placebo group (p < 0.05). After 7 years of follow-up, there was a sustained trend of decrease in clinical symptoms in desensitized patients relative to placebo. Serum sIgG4 was constantly present in all desensitized patients.

Conclusions: AIT may be beneficial for treating seniors with allergic rhinitis and allergies to house dust mites.

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过敏原免疫治疗老年变应性鼻炎患者HDM的远期疗效。

简介:过敏原免疫疗法(AIT)是一种有效的治疗变应性鼻炎，可能有长期的好处。然而，这些福利并没有严格规定给老年人。目的:评价AIT对60岁以上变应性鼻炎和屋尘螨(HDM)过敏患者7年的治疗效果。材料与方法:观察HDM-AIT治疗3年后的患者，评估治疗的持续临床效果。在舌下(SLIT)和注射AIT (SCIT)后监测7年的平均调整症状评分(AAdSS)和sIgG4。结果:HDM-AIT治疗3年后，基于AAdSS的SLIT组和SCIT组与基线组和安慰剂组比较，临床疗效显著(p < 0.05)。经过7年的随访，与安慰剂相比，脱敏患者的临床症状有持续下降的趋势。所有脱敏患者血清sIgG4均持续存在。结论:AIT对老年人变应性鼻炎和屋尘螨过敏有一定的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

$Powder Diffraction$

Powder Diffraction 工程技术-材料科学：表征与测试

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Powder Diffraction is a quarterly journal publishing articles, both experimental and theoretical, on the use of powder diffraction and related techniques for the characterization of crystalline materials. It is published by Cambridge University Press (CUP) for the International Centre for Diffraction Data (ICDD).