Samarium- 5-fluorouracil complex induces prominently the anticancer activity of human colon cancer cell line

Abstract

In the present study samarium 5-fluorouracil (5-FU) complex was prepared to enhance the effectiveness of the 5-FU drug. This complex was characterized by UV/VIS spectrometry high performance liquid chromatography and differential scanning calorimetry. Furthermore, the antitumor effect of the prepared complex was explored on the human colon cancer cell Caco2 via evaluation of the cytotoxic activity of this complex through trypan blue cell viability. Apoptosis was also assessed through morphological changes, by Annexin V=PI flow cytometric analysis. The results revealed that the trivalent Sm enhance the 5-FU effect against the chemo-resistant colorectal carcinoma cell line.