MANIFESTATIONS OF EPIDEMIC PROCESS OF ROTAVIRUS INFECTION IN NIZHNY NOVGOROD IN PRE-VACCINATION PERIOD

Abstract

Aim. Study the manifestations of epidemic process of rotavirus infection in Nizhny Novgorod in pre-vaccination period to evaluate the possible effect on morbidity for the rotavirus vaccine application introduction. Materials and methods. Rotavirus morbidity data were analyzed for the 12-year period (2005 - 2016), as well as its age and season distribution. Rotavirus genotyping was carried out using multiplex PCR and partial sequencing of VP4 and VP7 genes. Results. RVI morbidity in Nizhny Novgorod was shown to be at a moderate level when specific prophylaxis was not applied, multi-year dynamics for morbidity reflects the all-Russian state. 2015 - 2016 were characterized by intensification of the epidemic process in age groups of organized children (3 - 6 and 7 - 14) and adults. Season increase included December-May. seasonal morbidity maximums in different age groups took place during different months. Genetic structure of Nizhny Novgorod population PV-A during this time was presented by 10 types with G9P[8] (44,4%) dominating. Conclusion. Growth of RVI morbidity in Nizhny Novgorod in 2015 - 2016 and changes in age and season manifestations of the infection took place under the condition of change of the dominating genotype PV-A (G4P[8] to G9P[8]).