A Case of Canine Necrolytic Migratory Erythema Treated with Adipose-derived Stem Cells Therapy

Abstract

A 7-year-old castrated male Maltese was presented with multicentric erythema, erosion and crust on the face and footpads. A diagnosis of necrolytic migratory erythema (NME) due to hepatic cirrhosis was made following clinical and histopathological examinations. Cutaneous lesions and hypoalbuminemia improved after 32 days of combination treatment of liver support therapy, amino acid fluids, and intravenous adipose-derived stem cells (ADSCs) therapy. Skin lesions and hypoalbuminemia did not recur during 20 months of ADSCs therapy even after withdrawal of amino acid supplementation. These results suggest that ADSCs therapy could be an effective treatment option for canine NME.