Analysis on correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China

Abstract

Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.