Neurotrophic Effects of the Glycosaminoglycan C3 on Dendritic Arborization and Spines in the Adult Rat Hippocampus: A Quantitative Golgi Study

R. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, John M. Lee, S. Lorens, J. Fareed, I. Hanin
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引用次数: 8

Abstract

Glycosaminoglycans (GAGs) may be effective as a therapeutic strategy in the treatment of Alzheimer’s Disease (AD). Previous work from this group using a rat model showed that a single intra-amygdaloid injection of A$(25-35) could induce abnormal tauimmunoreactive perikarya in the hippocampus. Furthermore, administration of the GAG C3, an ultra low molecular weight heparin mixture of 4-10 oligosaccharides (MW~2.1) could decrease A$(25-35) -induced tau-2 immunoreactivity in this model of AD. In this study, we evaluated the effects of stereotaxic intra-amygdaloid injection of A$(25-35) (5 nml/3:l) and of C3-treatment (administered subcutaneously, s.c.) on dendritic morphology of Golgi-impregnated CA1 pyramids of the hippocampus. Subjects were young-adult, male F344 rats.
糖胺聚糖C3对成年大鼠海马树突和脊柱的神经营养作用:一项定量高尔基研究
糖胺聚糖(GAGs)可能是治疗阿尔茨海默病(AD)的有效治疗策略。该小组先前使用大鼠模型的工作表明,单次在杏仁核内注射a $(25-35)可以诱导海马核周异常的tau免疫反应。此外,给药GAG C3,一种由4-10寡糖组成的超低分子量肝素混合物(MW~2.1),可以降低A$(25-35)诱导的AD模型中tau-2的免疫反应性。在这项研究中,我们评估了立体定向杏仁核内注射A$(25-35) (5 nml/3: 1)和c3治疗(皮下注射,s.c)对高尔基浸染的海马CA1锥体树突形态的影响。实验对象为年轻成年雄性F344大鼠。
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