Assessment of Lactic Dehydrogenase in Cerebrospinal Fluid to Differentiate Between Structural And Non-Structural Central Nervous System Lesions in Patients with Diminished Level of Consciousness.

Abstract

Although both metabolic and structural abnormalities have devastating effect on the CNS, their treatment approaches and prognoses vary considerably. This study was conducted among 53 patients with diminished level of consciousness and CSF was analyzed for quantitative LDH(IU/L) value. In our study mean CSF-LDH was 25.19 ± 12.92 in patients with non-structural lesion and 86.53 ± 32.09 in patients with structural lesion of brain and difference was statistically highly significant (p<0.001). So CSF-LDH values can be used to differentiate between patients with structural pathology and those with metabolic disturbances.