Autoimmune polyglandular syndrome type 2 in pregnancy: a case report and review of the literature

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Perinatal Medicine Pub Date : 2022-01-01 DOI:10.1515/crpm-2020-0058

David R. Bayless, Trevor Caldarera, H. Harirah

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引用次数: 2

Abstract

Abstract Objectives Autoimmune polyglandular syndromes are uncommon heterogeneous conditions characterized by the association of two or more organ-specific endocrinopathies. Very few cases of these syndromes have been described during pregnancy. Here we report a case of autoimmune polyglandular syndrome type-2 presenting during pregnancy and complicated by preeclampsia with severe features. Case presentation The patient is a 35-year-old G7P0242 woman with a history of adrenal insufficiency, type 1 diabetes mellitus, and chronic lymphocytic thyroiditis. She was admitted to our institution at 34 weeks’ gestation for preterm contractions, nausea, and lower extremity edema for a few weeks prior to admission. At 35 weeks’ gestation, she developed preeclampsia with severe features requiring repeat cesarean section with good maternal and fetal outcomes. Recognizing the occurrence of this rare syndrome during pregnancy, adequate replacement of the deficient hormones, and close maternal and fetal surveillance are essential to achieving favorable outcomes. Conclusions To our knowledge, this is the first reported case of a pregnant woman with autoimmune polyglandular syndrome type-2 complicated by preeclampsia with severe features.

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妊娠期自身免疫性多腺综合征2型:1例报告及文献复习

自身免疫性多腺综合征是一种罕见的异质性疾病，其特征是两种或两种以上器官特异性内分泌病变的关联。在怀孕期间很少有这些综合征的病例被描述。在这里，我们报告一例自身免疫性多腺综合征2型在怀孕期间提出，并合并先兆子痫严重的特点。患者是一名35岁的G7P0242女性，有肾上腺功能不全、1型糖尿病和慢性淋巴细胞性甲状腺炎病史。她在妊娠34周时因早产、恶心和下肢水肿入院，入院前数周。在妊娠35周时，她出现了严重的先兆子痫，需要重复剖宫产，但母胎结局良好。认识到这种罕见综合征在妊娠期间的发生，充分补充缺乏的激素，密切监测母体和胎儿是获得良好结果的必要条件。结论:据我们所知，这是第一例报道的孕妇自身免疫性多腺综合征2型合并严重的先兆子痫的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Perinatal Medicine OBSTETRICS & GYNECOLOGY-

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期刊介绍： Case Reports in Perinatal Medicine is a double-blind peer-reviewed journal. The objective of the new journal is very similar to that of JPM. In addition to evidence-based studies, practitioners in clinical practice esteem especially exemplary reports of cases that reveal specific manifestations of diseases, its progress or its treatment. We consider case reports and series to be brief reports describing an isolated clinical case or a small number of cases. They may describe new or uncommon diagnoses, unusual outcomes or prognosis, new or infrequently used therapies and side effects of therapy not usually discovered in clinical trials. They represent the basic concept of experiences for studies on representative groups for further evidence-based research. The potential roles of case reports and case series are: Recognition and description of new diseases Detection of drug side effects (adverse or beneficial) Study of mechanisms of disease Medical education and audit Recognition of rare manifestations of disease.