Detection and Treatment of Hyperuricemia in Clinical Practice (According to the PROFILE Outpatient Registry)

IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Rational Pharmacotherapy in Cardiology Pub Date : 2022-09-08 DOI:10.20996/1819-6446-2022-08-12

N. Kutishenko, S. Martsevich, A. Zagrebelnyy, Y. Lukina, V. P. Voronina, N. Dmitrieva, O. Lerman, S. Tolpygina, S. V. Blagodatskikh, I. Budaeva, E. S. Nekoshnova, O. Drapkina

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引用次数: 0

Abstract

Aim. To study the frequency of detection of hyperuricemia (HU) in patients with high and very high cardiovascular risk and the frequency of prescribing drugs that lower serum uric acid (sUA) levels in real clinical practice.Material and methods: The general information of the study was based on the data of 2457 patients who were consistently included in the «PROFILE» registry until November 30, 2020: 1250 men (50.9%) and 1207 (49.1%) women. All patients with HU were selected (UA level ≥360 pmol/l in women, ≥420 pmol/l in men). At the stage of inclusion of the patient, data on MC indicators were available in 1777 (72.3%), upon re-examination - only 262 (33.2%) out of 790 patients who returned to the appointment.Results: The most common study of the level of sUA was performed in patients with gout (65.2%), with arterial hypertension (AH) and dyslipemia in 29.1% of cases, with diabetes mellitus (DM) - 30.1%, with impaired tolerance to glucose (IGT) - 40.2%, with other diseases, the proportion of patients with a known UA was even less. A positive relationship was found between the presence of AH and IGT with the frequency of UA control (p<0.001). In patients with AH, an increase in the level of sUA was detected significantly more often than in patients without AH (p<0.001), and less frequently in patients with DM and IGT (p<0.001 and p<0.01, respectively). The frequency of allopurinol prescribing was low: 49 (2%) patients received therapy, while of the 284 patients with HU, only 20 (7%) were prescribed allopurinol.Conclusion: in real clinical practice, only 29.1% of patients with AH and 20-25% of patients with other CVDs were monitored for sUA levels, every third patient had data on sUA levels at a repeat visit. In the presence of gout, the proportion of patients with current UA was higher (65%). For those with AH and IGT, positive correlations were found between the presence of the disease and control of sUA levels. A low frequency of prescribing drugs for the correction of HU was revealed.

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临床实践中高尿酸血症的检测和治疗(根据PROFILE门诊登记)

的目标。目的:研究实际临床中高、甚高心血管危险患者高尿酸血症(HU)的检出频率及降低血清尿酸(sUA)的用药频率。材料和方法:该研究的一般信息基于2457名患者的数据，这些患者一直被纳入到2020年11月30日的“PROFILE”注册表中:1250名男性(50.9%)和1207名女性(49.1%)。选择所有HU患者(女性UA≥360 pmol/l，男性≥420 pmol/l)。在纳入患者的阶段，1777年(72.3%)的MC指标数据可获得，在重新检查时- 790名患者中只有262人(33.2%)返回预约。结果:在痛风(65.2%)、动脉高血压(AH)和血脂异常(29.1%)、糖尿病(DM)(30.1%)、葡萄糖耐量受损(IGT)(40.2%)患者中进行sUA水平研究最为常见，其他疾病中已知UA的患者比例更少。AH和IGT的存在与UA控制频率呈正相关(p<0.001)。在AH患者中，sUA水平的升高明显高于无AH患者(p<0.001)，而在DM和IGT患者中，sUA水平的升高较少(分别为p<0.001和p<0.01)。处方别嘌呤醇的频率较低:49例(2%)患者接受了治疗，而284例HU患者中，只有20例(7%)患者服用了别嘌呤醇。结论:在实际的临床实践中，只有29.1%的AH患者和20-25%的其他心血管疾病患者接受了sUA水平的监测，三分之一的患者在复诊时有sUA水平的数据。在存在痛风的情况下，当前UA患者的比例更高(65%)。对于AH和IGT患者，发现疾病的存在与sUA水平的控制呈正相关。HU矫正用药频次较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rational Pharmacotherapy in Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.00

自引率

50.00%

发文量

审稿时长

6 weeks

期刊介绍： The primary goals of the Journal are consolidation of information on scientific and practical achievements in pharmacotherapy and prevention of cardiovascular diseases and continuing education of cardiologists and internists. The scientific concept of the edition suggests the publication of information on current achievements in cardiology, the results of national and international clinical trials. The Journal publishes original articles on the results of clinical trials designed to study the effectiveness and safety of drugs, analysis of clinical practice and its compliance with national and international recommendations, expert s’ opinions on a wide range of cardiology issues, associated conditions and clinical pharmacology. There is a heading “Preventive cardiology and public health” in the Journal to stimulate research interest in this highly demanded area. Memories of the outstanding people in medicine including cardiology, which are of great interest to historians of medicine, are published in "Our Mentors” heading.