Atorvastatin and gemfibrozil alter zebrafish behavior

IF 0.9 4区生物学 Q3 MARINE & FRESHWATER BIOLOGY

Marine and Freshwater Behaviour and Physiology Pub Date : 2023-05-11 DOI:10.1080/10236244.2023.2211220

Zeyana Al-Ghafri, A. Al-Habsi, Michael J. Barry

引用次数: 0

Abstract

ABSTRACT The pharmaceuticals atorvastatin and gemfibrozil are prescribed for the treatment of high blood cholesterol. Atorvastatin has been detected in surface waters at a concentrations of 250 ng/L while gemfibrozil at 0.5 μg/L. We tested the effects of atorvastatin and gemfibrozil individually and in combination on the swimming behavior and response of zebrafish (Danio rerio) to a conspecific alarm cue. We also measured whole-body cortisol and the effect of the alarm on metabolic rate. Fish exposed to nominal concentrations of 0.075 and 7.5 μg/L atorvastatin showed exaggerated responses to the alarm. In contrast, a high gemfibrozil concentration (nominal: 250 μg/L) alone and in combination with atorvastatin inhibited the alarm response suggesting an antagonistic effect. Neither drug affected total cortisol. After exposure to the alarm chemical the metabolic rate of control fish increased, but all other treatments decreased. This study shows that these drugs can effect behaviour at environmentally relevant concentrations.

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阿托伐他汀和吉非西可改变斑马鱼的行为

阿托伐他汀和吉非齐是治疗高血脂的处方药物。在地面水中检测到阿托伐他汀的浓度为250 ng/L，吉非罗齐的浓度为0.5 ng/L。我们测试了阿托伐他汀和吉非齐尔单独和联合使用对斑马鱼(Danio rerio)的游泳行为和对同一警报提示的反应的影响。我们还测量了全身皮质醇和警报对代谢率的影响。暴露于名义浓度0.075和7.5 μg/L的阿托伐他汀下的鱼对警报表现出夸张的反应。相比之下，高浓度的吉非齐尔(名义浓度:250 μg/L)单独使用和与阿托伐他汀联合使用可抑制报警反应，表明其具有拮抗作用。两种药物都不影响总皮质醇。暴露于警报化学物质后，对照鱼的代谢率增加，但所有其他处理都降低。这项研究表明，这些药物可以在与环境相关的浓度下影响行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine and Freshwater Behaviour and Physiology 生物-海洋与淡水生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Marine and Freshwater Behaviour and Physiology is devoted to the publication of papers covering field and laboratory research into all aspects of the behaviour and physiology of all marine and freshwater animals within the contexts of ecology, evolution and conservation. As the living resources of the world’s oceans, rivers and lakes are attracting increasing attention as food sources for humans and for their role in global ecology, the journal will also publish the results of research in the areas of fisheries biology and technology where the behaviour and physiology described have clear links to the contexts mentioned above. The journal will accept for publication Research Articles, Reviews, Rapid Communications and Technical Notes (see Instructions for authors for details). In addition, Editorials, Opinions and Book Reviews (invited and suggested) will also occasionally be published. Suggestions to the Editor-In-Chief for Special Issues are encouraged and will be considered on an ad hoc basis. With the goal of supporting early career researchers, the journal particularly invites submissions from graduate students and post-doctoral researchers. In addition to recognising the time constraints and logistical limitations their research often faces, and their particular need for a prompt review process, accepted articles by such researchers will be given prominence within the journal (see Instructions for authors for details).