Extracellular superoxide dismutase for the treatment of inflammatory skin diseases

Sunghwan Kim, Tae-Yoon Kim
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Abstract

The occurrence of chronic skin inflammatory diseases, such as psoriasis and atopic dermatitis, has been increasing. However, currently available medicines are not sufficient to treat skin inflammatory diseases, so the development of effective medicines without the side effects has been demanded. Oxidative stress by accumulated reactive oxygen species induces and/or promotes inflammatory reactions. Therefore, many anti-oxidant molecules have been reported to have anti-inflammatory effects. Extracellular superoxide dismutase (SOD3) is an endogenous anti-oxidant enzyme that dismutates superoxide radicals into oxygen or hydrogen peroxide molecules in the extracellular space. A series of reports has suggested that exogenous recombinant SOD3 represses inflammatory responses not only by directly reducing reactive oxygen species but also by inhibiting cellular signaling pathways. Here, we demonstrate the potential of SOD3 as a novel biomedicine for treating inflammatory skin diseases and review preparations of ac...
细胞外超氧化物歧化酶用于治疗炎症性皮肤病
慢性皮肤炎症性疾病,如牛皮癣和特应性皮炎的发病率一直在增加。然而,目前可用的药物不足以治疗皮肤炎症性疾病,因此要求开发无副作用的有效药物。积累的活性氧引起的氧化应激诱导和/或促进炎症反应。因此,据报道,许多抗氧化分子具有抗炎作用。细胞外超氧化物歧化酶(SOD3)是一种内源性抗氧化酶,可将细胞外空间的超氧化物自由基歧化成氧或过氧化氢分子。一系列报道表明,外源性重组SOD3不仅通过直接减少活性氧,而且通过抑制细胞信号通路来抑制炎症反应。在此,我们展示了SOD3作为一种治疗炎症性皮肤病的新型生物医学的潜力,并对其制备方法进行了综述。
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