Effect of Metronidazole on Spermatogenesis, Plasma Gonadotrophins and Testosterone in Male Rats

D. Sohrabi, A. Mohsen, A. Melati
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引用次数: 20

Abstract

Metronidazole and it’s derivatives are drugs that have both antiprotozoal and anti bacterial effect.The reproductive toxicity of metronidazole has been shown in some studies. To investigate the effect of metronidazole on spermatogenesis in adult male rats, this study was designed. Eighteen wistar male rats (70-90days old) were randomly divided into three groups. Animals in group I (Control group) were administered the water. Animals in groups II, III were administered metronidazole at doses of 200 and 400 mg/kg/day for 60 days. Different varieties of germ cells at stage VII seminiferous epithelium cycle, namely, type A spermatogonia (ASg), preleptotene spermatocytes (pLSc) and step 7 spermatids (7Sd) were quantitatively evaluated, along with radioimmunoassay of plasma follicle-stimulating hormone (FSH), luteiniging hormone (LH), testosterone assessment. In the 200 and 400 mg/kg groups, there were significant decreases in the testes and accessory sex organ weights, plasma concentrations of LH, FSH and testosterone with massive degeneration of all the germ cells at stage VII. It is concluded that metronidazole has a suppressive influence on spermatogenesis and sex hormones in rats.
甲硝唑对雄性大鼠精子发生、血浆促性腺激素和睾酮的影响
甲硝唑及其衍生物是具有抗原虫和抗菌双重作用的药物。甲硝唑的生殖毒性已在一些研究中得到证实。为了研究甲硝唑对成年雄性大鼠精子发生的影响,本实验设计了甲硝唑对成年雄性大鼠精子发生的影响。选取70 ~ 90日龄wistar雄性大鼠18只,随机分为3组。第一组(对照组)给水。II、III组分别给予甲硝唑200、400 mg/kg/d,连续60 d。定量评价第七期精原细胞A型精原细胞(ASg)、精原细胞pLSc和第七期精母细胞7Sd,并测定血浆促卵泡激素(FSH)、促黄体生成素(LH)和睾酮水平。200和400 mg/kg组睾丸和副性器官重量显著降低,血浆LH、FSH和睾酮浓度显著降低,生殖细胞大量退化。由此可见,甲硝唑对大鼠精子发生和性激素有抑制作用。
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