Bioactive calcium phosphate foam ceramics modified by biomimetic apatite

Q4 Chemistry
V. Krut’ko, L. Y. Maslova, O. Musskaya, T. V. Safronova, N. Budeiko, A. Kulak
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引用次数: 0

Abstract

By combining the method of replication of polyurethane foam matrices at 1200 °C and modification in model SBF (Simulated Body Fluid) solutions of various compositions, open-pore calcium phosphate foam ceramics with a porosity of 53-60 % was obtained. The architecture and morphology of the calcium phosphate foam ceramics surface was formed by using polyurethane foam matrices («Granufoam», «STR») with different porosity and quantity of open pores. Modification of the calcium phosphate foam ceramics in SBF solutions of various compositions leads to a slight decrease in porosity to 3 %, which indicates the formation of an ultrathin apatite layer. The calcium phosphate-modified foam ceramics consisted of β-tricalcium phosphate, β-calcium pyrophosphate, α-tricalcium phosphate, and biomimetic apatite. In the standard SBF solution, the formation of apatite on calcium phosphate foam ceramics occurs slowly (14-56 days) and the strength increases by a factor of 2 as compared to the initial one. Soaking of calcium phosphate foam ceramics in SBF without HCO3- leads to the formation of biomimetic apatite with inclusions of calcium chloride dihydrophosphate in spherulites. Modification in a 5-fold concentrated SBF solution for 3-5 days at 37 °C makes it possible to form 6-10 times more biomimetic apatite compared to standard SBF with a 2.5-fold increase in static strength to 0.05 MPa. It has been established that at 800 °C biomimetic apatite crystallizes into β- tricalcium phosphate.
仿生磷灰石改性生物活性磷酸钙泡沫陶瓷
通过在1200℃下复制聚氨酯泡沫基质的方法,并在不同成分的模拟体液模型溶液中进行改性,获得了孔隙率为53- 60%的开孔磷酸钙泡沫陶瓷。磷酸钙泡沫陶瓷表面的结构和形态是通过使用具有不同孔隙率和开孔数量的聚氨酯泡沫基质(«Granufoam»,«STR»)形成的。在不同组分的SBF溶液中对磷酸钙泡沫陶瓷进行改性,孔隙率略微降低至3%,表明形成了超薄磷灰石层。磷酸钙改性泡沫陶瓷由β-磷酸三钙、β-焦磷酸钙、α-磷酸三钙和仿生磷灰石组成。在标准SBF溶液中,磷酸钙泡沫陶瓷表面磷灰石的形成较慢(14-56天),强度较初始强度增加2倍。在不含HCO3-的SBF中浸泡磷酸钙泡沫陶瓷,会在球晶中形成带有氯化钙二氢磷酸包体的仿生磷灰石。在浓度为5倍的SBF溶液中,在37℃下进行3-5天的改性,可以形成比标准SBF多6-10倍的仿生磷灰石,静态强度提高2.5倍,达到0.05 MPa。在800℃时,仿生磷灰石结晶成β-磷酸三钙。
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
38
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