St. John’s wort as an herbal treatment for depression and general considerations for the use of herbs in mental health

Abstract

St. John’s wort (SJW) is a common plant that has become popular in Europe and the US for treatment of mild-to-moderate depression. Research has shown it is effective in alleviating symptoms of depression with minimal side effects and is also useful in premenstrual syndrome. It has an excellent safety profile, although some known drug interactions. Confusion has arisen recently regarding the appropriate use of SJW and this review provides clear guidelines. General considerations for the use of herbs in mental health, as well as a useful summary, are also provided.