SYNTHESIS, GREEN METRICS EVALUATION AND ANTIBACTERIAL ACTIVITY OF 3,4,5-TRIMETHOXY–N- [SUBSTITUTED (ARYL/HETEROARYL) METHYLENE)BENZENAMINE DERIVATIVES

Abstract

Schiff bases, such as nitrofurantoin or nifuroxazide, are commonly applied in medicine as antibacterial agents. They are well known for their biological application as antibacterial, antifungal, antiviral, antiHIV, anti-protozoal, anti-cancer agents. The present paper describes the synthesis of Schiff‟s base 3,4,5-trimethoxy-N[substituted(Aryl/Hetero-Aryl)methylene)benzenamine derivatives 5am from commercially available gallic acid. These derivatives were synthesized by condensation with 3,4,5-trimethoxyanline using various aromatic and hetero-aromatic aldehydes in presence of ZnO Nano particles at room temperature. Furthermore, the present paper describes the green metrics evaluation data for the synthesized Schiff‟s base derivatives (5a-m) and its associated intermediates. In addition to the above, these compounds were screened for their anti-